Neurokinin-1 receptor antagonists as antitumor drugs in gastrointestinal cancer: A new approach
Gastrointestinal (GI) cancer is the term for a group of cancers affecting the digestive system.After binding to the neurokinin-1 (NK-1) receptor, the undecapeptide substance P (SP) regulates GI cancer cell proliferation and migration for invasion and metastasis, and controls endothelial cell proliferation for angiogenesis.SP also exerts an antiapop